Pregnenolone is the hormone best known for helping mood, memory and sleep. It is made from cholesterol in our diet as well as from the adrenal gland, liver, brain, testicles, and ovaries.  

Pregnenolone is the precursor from which almost all other hormones are made including DHEA, progesterone, testosterone, estrogen, and cortisol. Pregnenolone can help reduce fatigue caused by high stress. By improving memory and well-being, patients report a higher quality of life.

By age 75, we produce 60% less pregnenolone than we did in our 30’s. Pregnenolone levels can decline when our body senses our cortisol level is low. Our body will steal pregnenolone to make cortisol.  Pregnenolone is one of the markers for aging.

Overall benefits of pregnenolone include:

  • Improved memory
  • Improvement with depression
  • Improvement of autoimmune diseases (Rheumatoid Arthritis and Lupus)
  • Improvement in osteoarthritis
  • Improvement in deep sleep
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